Journal Articles Letters in Organic Chemistry Year : 2018

Fused Bis-lactams to Spirolactams: A New Member of the Family of Ring- Contraction Reaction

Abstract

A new ring contraction of fused bis-lactams into spirolactams is presented here. In the presence of a triflate catalyst in various solvents under microwave irradiation, this rearrangement allows a clean conversion of some fused bicycles into spirocycles with good yields. The interest of this work thus lies in the use of activated 2,5-diketopiperazines as starting materials and demonstrates the wide range of applications of ring contraction reactions

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hal-02388789 , version 1 (15-12-2020)

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Guilhem Chaubet, Mathéo Berthet, Morgane Pasco, Guillaume Cazals, Aurelien Lebrun, et al.. Fused Bis-lactams to Spirolactams: A New Member of the Family of Ring- Contraction Reaction. Letters in Organic Chemistry, 2018, 15 (12), pp.1046-1055. ⟨10.2174/1570178615666180326160131⟩. ⟨hal-02388789⟩
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