The flexible mind is associated with the catechol-O-methyltransferase (COMT) Val158Met polymorphism: Evidence for a role of dopamine in the control of task-switching - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Neuropsychologia Année : 2010

The flexible mind is associated with the catechol-O-methyltransferase (COMT) Val158Met polymorphism: Evidence for a role of dopamine in the control of task-switching

Lorenza S Colzato
  • Fonction : Auteur
Florian Waszak
Sander Nieuwenhuis
  • Fonction : Auteur
Danielle Posthuma
  • Fonction : Auteur
Bernhard Hommel
  • Fonction : Auteur

Résumé

Genetic variability related to the catechol-O-methyltransferase (COMT) gene (Val 158 Met polymorphism) has received increasing attention as a possible modulator of cognitive control functions. Recent evidence suggests that the Val 158 Met genotype may differentially affect cognitive stability and flexibility, in such a way that Val/Val homozygous individuals (who possess low prefrontal dopamine levels) may show more pronounced cognitive flexibility than Met/-carriers (who possess high prefrontal dopamine levels). To test this, healthy humans (n = 87), genotyped for the Val 158 Met polymorphism at the COMT gene, performed a task-switching paradigm, which provides a relatively diagnostic index of cognitive flexibility. As predicted, Met/-carriers showed larger switching costs (i.e., less cognitive flexibility), F(1,85) = 4.28, p < 0.05, than Val/Val homozygous individuals. Our findings support the idea that low prefrontal dopamine levels promote cognitive flexibility.

Dates et versions

hal-02386390 , version 1 (03-12-2019)

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Citer

Lorenza S Colzato, Florian Waszak, Sander Nieuwenhuis, Danielle Posthuma, Bernhard Hommel. The flexible mind is associated with the catechol-O-methyltransferase (COMT) Val158Met polymorphism: Evidence for a role of dopamine in the control of task-switching. Neuropsychologia, 2010, 48 (9), pp.2764-2768. ⟨10.1016/j.neuropsychologia.2010.04.023⟩. ⟨hal-02386390⟩

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