Glucocorticoid Regulation of Human and Ovine Parturition: The Relationship Between Fetal Hypothalamic-Pituitary-Adrenal Axis Activation and Intrauterine Prostaglandin Production - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Biology of Reproduction Année : 2001

Glucocorticoid Regulation of Human and Ovine Parturition: The Relationship Between Fetal Hypothalamic-Pituitary-Adrenal Axis Activation and Intrauterine Prostaglandin Production

W.L. Whittle
  • Fonction : Auteur
F.A. Patel
  • Fonction : Auteur
N. Alfaidy
  • Fonction : Auteur
  • PersonId : 964984
M. Fraser
  • Fonction : Auteur
S. Gyomorey
  • Fonction : Auteur
W. Gibb
  • Fonction : Auteur
J.R.G. Challis
  • Fonction : Auteur

Résumé

Birth in many animal species and in humans is associated with activation of hypothalamic-pituitary-adrenal function in the fetus and the increased influence of glucocorticoids on trophoblast cells of the placenta and fetal membranes. We suggest that in ovine pregnancy glucocorticoids directly increase fetal placental prostaglandin production, and indirectly increase prostaglandin production by maternal uterine tissues through the stimulation of placental estradiol synthesis. The events of ovine parturition are compared with those of human parturition. In the latter, we suggest similar direct effects of glucocorticoids on prostaglandin synthesis and metabolism in fetal membranes and similar indirect effects mediated by glucocorticoid-stimulated increases in intrauterine corticotropin-releasing hormone expression.

Dates et versions

hal-02385762 , version 1 (29-11-2019)

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W.L. Whittle, F.A. Patel, N. Alfaidy, A.C. Holloway, M. Fraser, et al.. Glucocorticoid Regulation of Human and Ovine Parturition: The Relationship Between Fetal Hypothalamic-Pituitary-Adrenal Axis Activation and Intrauterine Prostaglandin Production. Biology of Reproduction, 2001, 64 (4), pp.1019-1032. ⟨10.1095/biolreprod64.4.1019⟩. ⟨hal-02385762⟩
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