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Article Dans Une Revue RSC Advances Année : 2016

Poly(ethylene) glycols and mechanochemistry for the preparation of bioactive 3,5-disubstituted hydantoins

Résumé

Mechanochemistry was effective for the preparation of 3,5-disubstituted hydantoins from a-amino methyl esters, using either 1,1 0-carbonyldiimidazole (CDI) or alkyl isocyanates. The preparation of the antimicrobial additives, 3-allyl-5,5 0-dimethyl hydantoin (ADMH) and 1-chloro-3-ethyl-5,5 0-dimethyl hydantoin (CEDMH) were performed by grinding. A chlorination reaction, never described before by mechanochemistry was achieved by Ca(ClO) 2 , while the preparation of the bioactive anticonvulsant marketed drug ethotoin was achieved by a novel approach based on poly(ethylene) glycol (PEGs) assisted grinding.
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Dates et versions

hal-02385431 , version 1 (28-11-2019)

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Laure Konnert, M. Dimassi, Lori Gonnet, Frédéric Lamaty, Evelina Colacino. Poly(ethylene) glycols and mechanochemistry for the preparation of bioactive 3,5-disubstituted hydantoins. RSC Advances, 2016, 6 (43), pp.36978-36986. ⟨10.1039/c6ra03222b⟩. ⟨hal-02385431⟩
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