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Article Dans Une Revue Bioorganic and Medicinal Chemistry Letters Année : 2000

A convenient extension of the Wessely–Moser rearrangement for the synthesis of substituted alkylaminoflavones as neuroprotective agents in vitro

Résumé

A series of 8-alkylamino-5,7-dihydroxyflavones was prepared from chrysine via a seven step sequence. The synthesis of their 6-alkylamino isomers could be subsequently accomplished through a convenient extension of the Wessely-Moser rearrangement. These compounds were found to be efficient neuroprotective agents in vitro.
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hal-02385135 , version 1 (08-02-2021)

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Ronan Larget, Brian Lockhart, Pierre Renard, Martine Largeron. A convenient extension of the Wessely–Moser rearrangement for the synthesis of substituted alkylaminoflavones as neuroprotective agents in vitro. Bioorganic and Medicinal Chemistry Letters, 2000, 10 (8), pp.835-838. ⟨10.1016/S0960-894X(00)00110-4⟩. ⟨hal-02385135⟩

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