Simultaneously electrogenerated diene and dienophile: A unique access to novel polyfunctionalized 1,4-benzoxazine derivatives as neuroprotective agents - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Electrochimica Acta Année : 2005

Simultaneously electrogenerated diene and dienophile: A unique access to novel polyfunctionalized 1,4-benzoxazine derivatives as neuroprotective agents

Estelle Blattes
  • Fonction : Auteur
Maurice-Bernard Fleury
  • Fonction : Auteur

Résumé

New insights into the scope of a multistep one-pot electrochemical synthesis of polyfunctionalized 2-alkylamino-1,4-benzoxazine derivatives are delineated. This cascade sequence, wherein both cycloaddition partners are generated in situ, at room temperature, under metal-free conditions, should be useful to generate libraries of heterocycles which constitute the molecular framework of medicinally relevant compounds. In this respect, 2alkylamino-1,4-benzoxazine derivatives proved to be potent neuroprotective agents in vitro, on immortalized HT22 hippocampal cell cultures, and in vivo, in an animal model mimicking the cerebral palsy in human newborns.
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Dates et versions

hal-02385009 , version 1 (16-02-2021)

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Estelle Blattes, Maurice-Bernard Fleury, Martine Largeron. Simultaneously electrogenerated diene and dienophile: A unique access to novel polyfunctionalized 1,4-benzoxazine derivatives as neuroprotective agents. Electrochimica Acta, 2005, 50 (25-26), pp.4902-4910. ⟨10.1016/j.electacta.2004.12.051⟩. ⟨hal-02385009⟩

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