Protocols for the Catalytic Oxidation of Primary Amines to Imines
Résumé
The catalytic oxidation of amines to imines is of current and intense interest owing to the importance of imines as pivotal intermediates in the synthesis of fine chemicals and numerous biologically active compounds. Whereas considerable efforts were made to develop efficient methods for the oxidation of secondary amines to imines, until recently little attention was given to the oxidation of primary amines, probably because the generated imines are intermediate products that are easily dehydrogenated to nitriles. A surge of activity in this area originates with the discovery of new catalytic systems which allow the oxidation of primary amines to imines under green conditions. This microreview focuses on the major achievements during the last five years.
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