Journal Articles Experimental Neurology Year : 2000

Open-Loop and Closed-Loop Optokinetic Nystagmus (OKN) in Myasthenia Gravis and Nonmyasthenic Subjects

Min Wei
  • Function : Author
Fuchuan Sun
  • Function : Author
Jing Tian
Xiangjun Chen
  • Function : Author
Chuanzhen Lu
  • Function : Author

Abstract

Optokinetic nystagmus (OKN) eye movements of my-asthenia gravis (MG) and nonmyasthenic ocular pal-sies, and normal subjects were examined under closed-loop and open-loop conditions. The open-loop OKN condition was achieved by adding the signal of eye-movement velocity of OKN to the computer-generated signal controlling the stimulus grating moving. The OKN was recorded by means of electromagnetic search scleral coil technique. In MG patients, the open-loop gains of OKN increased significantly after the intramuscular injection of an acetylcholinesterase inhibitor, neostigmine, while the closed-loop OKN gains were not significantly changed. Both the closed-loop and open-loop OKN gains of normal subjects and nonmyasthenic patients were not increased for the administration of neostigmine. The experimental results indicated that the open-loop OKN gain could be sensitive to reflect the changes of the function of neu-romuscular junction in MG patients.

Dates and versions

hal-02384388 , version 1 (06-12-2019)

Identifiers

Cite

Qing Yang, Min Wei, Fuchuan Sun, Jing Tian, Xiangjun Chen, et al.. Open-Loop and Closed-Loop Optokinetic Nystagmus (OKN) in Myasthenia Gravis and Nonmyasthenic Subjects. Experimental Neurology, 2000, ⟨10.1006/exnr.2000.7503⟩. ⟨hal-02384388⟩
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