Assembly of the Entire Carbon Backbone of a Stereoisomer of the Antitumor Marine Natural Product Hemicalide - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Chemistry - A European Journal Année : 2019

Assembly of the Entire Carbon Backbone of a Stereoisomer of the Antitumor Marine Natural Product Hemicalide

Eric Auclair
  • Fonction : Auteur
Serge Sablé
  • Fonction : Auteur
Christophe Meyer
  • Fonction : Auteur
  • PersonId : 1045869
Janine Cossy
Marie-Isabelle Lannou
Janick Ardisson
  • Fonction : Auteur
  • PersonId : 1048583

Résumé

A strategy for the assembly of the entire carbon backbone of a stereoisomer of the antitumor marine natural product hemicalide has been investigated. The devised convergent approach relies on Horner–Wadsworth–Emmons and Julia–Kocienski olefination reactions for the construction of the C6=C7 and C34=C35 double bonds, respectively, an aldol reaction to create the C27−C28 bond, and a Suzuki–Miyaura cross‐coupling as the endgame to form the C15−C16 bond.
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Dates et versions

hal-02379818 , version 1 (25-11-2019)

Identifiants

Citer

Camille Lecourt, Sabrina Dhambri, Khalil Yamani, Guillaume Boissonnat, Simon Specklin, et al.. Assembly of the Entire Carbon Backbone of a Stereoisomer of the Antitumor Marine Natural Product Hemicalide. Chemistry - A European Journal, 2019, 25 (11), pp.2745-2749. ⟨10.1002/chem.201806327⟩. ⟨hal-02379818⟩
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