The acoustic coupling between the injection system and the acoustic fluctuations in liquid rocket engine combustion chambers is an important issue in the understanding of the thermo-acoustic instability phenomenon. This paper presents results of a large parametric investigation of a two-phase injection system acoustic response, to the excitation produced by a high-amplitude transverse acoustic field forced into a main resonant cavity. Two domes, one for the gas and one for the liquid, were expressly designed to feed three identical coaxial injectors. Characterization of domes internal mode shapes were performed by measuring pressure signals at different locations in the domes. Experimental mode shapes showed good agreement with those predicted by numerical simulations. Acoustic pressure amplitudes up to 17% of the the one induced in the main cavity can be found in both gas and liquid dome. The maximum acoustic response is observed in a configuration in which acoustic boundary conditions does not correspond to the maximum injection system solicitation conditions.