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Article Dans Une Revue Proceedings of the National Academy of Sciences of the United States of America Année : 2019

Persistence of learning-induced synapses depends on neurotrophic priming of glucocorticoid receptors

Résumé

Signal transduction upon activation of receptor tyrosine kinases by neurotrophins and nuclear receptors by glucocorticoids is essential for homeostasis. Phosphorylation (PO4) is one way these receptors communicate with one another to support homeostatic reactions in learning and memory. Using a newly developed glucocorticoid receptor (GR)-PO4–deficient knock-in mouse, we show that consolidation of learning-induced neuroplasticity depends on both GR-PO4 and neurotrophic signaling. Cross-talk between these pathways affects experience-dependent neuroplasticity and behavior, extending previous implications of neurotrophic priming of glucocorticoid response for adaptive plasticity to chronic stress and antidepressant response. Therefore, a disruption of cross-talk between these pathways by, for example, the misalignment of circadian glucocorticoid release and experience-dependent neurotrophic signaling may contribute to the pathophysiology of stress-related disorders.
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Dates et versions

hal-02367992 , version 1 (18-11-2019)

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Margarita Arango-Lievano, Amélie Borie, Yann Dromard, Maxime Murat, Michel G Desarménien, et al.. Persistence of learning-induced synapses depends on neurotrophic priming of glucocorticoid receptors. Proceedings of the National Academy of Sciences of the United States of America, 2019, 116 (26), pp.13097-13106. ⟨10.1073/pnas.1903203116⟩. ⟨hal-02367992⟩
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