Diversification of human plasmacytoid predendritic cells in response to a single stimulus
Solana Alculumbre
(1)
,
Violaine Saint-André
(2)
,
Jérémy Di Domizio
(3)
,
Pablo Vargas
(4)
,
Philemon Sirven
(1)
,
Pierre Bost
(1, 5, 6)
,
Mathieu L Maurin
(1)
,
Paolo Maiuri
(7, 8)
,
Maxime Wery
(9, 2)
,
Mabel San Roman
(1)
,
Léa Savey
(10)
,
Maxime Touzot
(11)
,
Benjamin Terrier
(12)
,
David Saadoun
(10)
,
Curdin Conrad
(3)
,
Michel Gilliet
(3)
,
Antonin Morillon
(2)
,
Vassili Soumelis
(1, 13)
1
U932 -
Immunité et cancer
2 DIG CANCER - Dynamique de l'information génétique : bases fondamentales et cancer
3 CHUV - Centre Hospitalier Universitaire Vaudois = Lausanne University Hospital [Lausanne]
4 Biologie Cellulaire et Cancer
5 ENS-PSL - École normale supérieure - Paris
6 PSL - Université Paris Sciences et Lettres
7 Institut Curie [Paris]
8 IFOM - IFOM, Istituto FIRC di Oncologia Molecolare
9 DIG CANCER - Dynamique de l'information génétique : bases fondamentales et cancer
10 CHU Pitié-Salpêtrière [AP-HP]
11 AURA Paris - Plaisance
12 Centre National de Référence Maladies Systémiques et Autoimmunes Rares
13 CIC1428 IGR-CURIE
2 DIG CANCER - Dynamique de l'information génétique : bases fondamentales et cancer
3 CHUV - Centre Hospitalier Universitaire Vaudois = Lausanne University Hospital [Lausanne]
4 Biologie Cellulaire et Cancer
5 ENS-PSL - École normale supérieure - Paris
6 PSL - Université Paris Sciences et Lettres
7 Institut Curie [Paris]
8 IFOM - IFOM, Istituto FIRC di Oncologia Molecolare
9 DIG CANCER - Dynamique de l'information génétique : bases fondamentales et cancer
10 CHU Pitié-Salpêtrière [AP-HP]
11 AURA Paris - Plaisance
12 Centre National de Référence Maladies Systémiques et Autoimmunes Rares
13 CIC1428 IGR-CURIE
Violaine Saint-André
- Fonction : Auteur
- PersonId : 735015
- IdHAL : violaine-saint-andre
- ORCID : 0000-0002-2162-0909
Benjamin Terrier
- Fonction : Auteur
- PersonId : 762205
- ORCID : 0000-0001-6612-7336
- IdRef : 13141142X
David Saadoun
- Fonction : Auteur
- PersonId : 759697
- ORCID : 0000-0003-3628-9996
- IdRef : 119038765
Antonin Morillon
- Fonction : Auteur
- PersonId : 971712
- IdHAL : antonin-morillon
- ORCID : 0000-0002-0575-5264
- IdRef : 139727000
Vassili Soumelis
Connectez-vous pour contacter l'auteur
- Fonction : Auteur correspondant
- PersonId : 1019664
Connectez-vous pour contacter l'auteur
Résumé
Innate immune cells adjust to microbial and inflammatory stimuli through a process termed environmental plasticity, which links a given individual stimulus to a unique activated state. Here, we report that activation of human plasmacytoid predendritic cells (pDCs) with a single microbial or cytokine stimulus triggers cell diversification into three stable subpopulations (P1-P3). P1-pDCs (PD-L1+CD80-) displayed a plasmacytoid morphology and specialization for type I interferon production. P3-pDCs (PD-L1-CD80+) adopted a dendritic morphology and adaptive immune functions. P2-pDCs (PD-L1+CD80+) displayed both innate and adaptive functions. Each subpopulation expressed a specific coding- and long-noncoding-RNA signature and was stable after secondary stimulation. P1-pDCs were detected in samples from patients with lupus or psoriasis. pDC diversification was independent of cell divisions or preexisting heterogeneity within steady-state pDCs but was controlled by a TNF autocrine and/or paracrine communication loop. Our findings reveal a novel mechanism for diversity and division of labor in innate immune cells.
Domaines
Immunité innéeFormat du dépôt | Notice |
---|---|
Type de dépôt | Article dans une revue |
Titre |
en
Diversification of human plasmacytoid predendritic cells in response to a single stimulus
|
Résumé |
en
Innate immune cells adjust to microbial and inflammatory stimuli through a process termed environmental plasticity, which links a given individual stimulus to a unique activated state. Here, we report that activation of human plasmacytoid predendritic cells (pDCs) with a single microbial or cytokine stimulus triggers cell diversification into three stable subpopulations (P1-P3). P1-pDCs (PD-L1+CD80-) displayed a plasmacytoid morphology and specialization for type I interferon production. P3-pDCs (PD-L1-CD80+) adopted a dendritic morphology and adaptive immune functions. P2-pDCs (PD-L1+CD80+) displayed both innate and adaptive functions. Each subpopulation expressed a specific coding- and long-noncoding-RNA signature and was stable after secondary stimulation. P1-pDCs were detected in samples from patients with lupus or psoriasis. pDC diversification was independent of cell divisions or preexisting heterogeneity within steady-state pDCs but was controlled by a TNF autocrine and/or paracrine communication loop. Our findings reveal a novel mechanism for diversity and division of labor in innate immune cells.
|
Auteur(s) |
Solana Alculumbre
1
, Violaine Saint-André
2
, Jérémy Di Domizio
3
, Pablo Vargas
4
, Philemon Sirven
1
, Pierre Bost
1, 5, 6
, Mathieu L Maurin
1
, Paolo Maiuri
7, 8
, Maxime Wery
9, 2
, Mabel San Roman
1
, Léa Savey
10
, Maxime Touzot
11
, Benjamin Terrier
12
, David Saadoun
10
, Curdin Conrad
3
, Michel Gilliet
3
, Antonin Morillon
2
, Vassili Soumelis
1, 13
1
U932 -
Immunité et cancer
( 81436 )
- INSTITUT CURIE - SECTION DE RECHERCHE
26 RUE D'ULM
75248 PARIS
- France
2
DIG CANCER -
Dynamique de l'information génétique : bases fondamentales et cancer
( 541952 )
- France
3
CHUV -
Centre Hospitalier Universitaire Vaudois = Lausanne University Hospital [Lausanne]
( 329903 )
- Rue du Bugnon 21
CH-1011 Lausanne, Vaud
- Suisse
4
Biologie Cellulaire et Cancer
( 580753 )
- 26 Rue d'Ulm 75248 PARIS CEDEX 05
- France
5
ENS-PSL -
École normale supérieure - Paris
( 59704 )
- 45, Rue d'Ulm - 75230 Paris cedex 05
- France
6
PSL -
Université Paris Sciences et Lettres
( 564132 )
- 60 rue Mazarine 75006 Paris
- France
7
Institut Curie [Paris]
( 301888 )
- 26 rue d'Ulm - 75248 Paris
- France
8
IFOM -
IFOM, Istituto FIRC di Oncologia Molecolare
( 117093 )
- Via Adamello 16, 20139 - Milan, Italy
- Italie
9
DIG CANCER -
Dynamique de l'information génétique : bases fondamentales et cancer
( 122765 )
- France
10
CHU Pitié-Salpêtrière [AP-HP]
( 353778 )
- 47-83 Boulevard de l'Hôpital, 75013 Paris
- France
11
AURA Paris - Plaisance
( 534350 )
- 185 A rue Raymond Losserand 75014 Paris.
- France
12
Centre National de Référence Maladies Systémiques et Autoimmunes Rares
( 450604 )
- 27 Rue du Faubourg Saint-Jacques, 75014 Paris
- France
13
CIC1428 IGR-CURIE
( 494854 )
- Laboratoire d'Immunologie / Unité Inserm 932 - 26 rue d'Ulm 75005 Paris Cedex.
- France
|
Langue du document |
Anglais
|
Nom de la revue |
|
Vulgarisation |
Non
|
Date de publication |
2018-01
|
Audience |
Internationale
|
Comité de lecture |
Oui
|
Volume |
19
|
Numéro |
1
|
Page/Identifiant |
63-75
|
Commentaire |
Comment in : Plasmacytoid dendritic cells: Division of labour./
Bird L. Nat Rev Immunol. 2017 Dec 22;18(1):2-3. doi: 10.1038/nri.2017.153. PMID: 29269763
|
Domaine(s) |
|
Collaboration/Projet |
|
Financement |
|
Projet(s) ANR |
|
DOI | 10.1038/s41590-017-0012-z |
Pubmed Id | 29203862 |
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