Live Imaging of HIV-1 Transfer across T Cell Virological Synapse to Epithelial Cells that Promotes Stromal Macrophage Infection - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Cell Reports Année : 2018

Live Imaging of HIV-1 Transfer across T Cell Virological Synapse to Epithelial Cells that Promotes Stromal Macrophage Infection

Résumé

Graphical Abstract Highlights d HIV-1-infected T cells form viral synapse with the epithelium in reconstructed mucosa d These viral synapse dynamics were recorded by live imaging for the first time d HIV-1 formed at the viral synapse crosses the epithelium by transcytosis d Transcytosed HIV-1 targets stromal macrophages, resulting in their latent infection In Brief Real et al. established by live imaging the dynamics of virological synapses formed between HIV-1-infected T cells and the epithelium at the surface of a human reconstructed mucosa. HIV-1 virions formed at the viral synapse cross the epithelium and reach the mucosal stroma, where the virus establishes a latent infection in macrophages.
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Dates et versions

hal-02348307 , version 1 (05-11-2019)

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Fernando Real, Alexis Sennepin, Yonatan Ganor, Alain Schmitt, Morgane Bomsel. Live Imaging of HIV-1 Transfer across T Cell Virological Synapse to Epithelial Cells that Promotes Stromal Macrophage Infection. Cell Reports, 2018, 23 (6), pp.1794-1805. ⟨10.1016/j.celrep.2018.04.028⟩. ⟨hal-02348307⟩

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