Live Imaging of HIV-1 Transfer across T Cell Virological Synapse to Epithelial Cells that Promotes Stromal Macrophage Infection
Résumé
Graphical Abstract Highlights d HIV-1-infected T cells form viral synapse with the epithelium in reconstructed mucosa d These viral synapse dynamics were recorded by live imaging for the first time d HIV-1 formed at the viral synapse crosses the epithelium by transcytosis d Transcytosed HIV-1 targets stromal macrophages, resulting in their latent infection In Brief Real et al. established by live imaging the dynamics of virological synapses formed between HIV-1-infected T cells and the epithelium at the surface of a human reconstructed mucosa. HIV-1 virions formed at the viral synapse cross the epithelium and reach the mucosal stroma, where the virus establishes a latent infection in macrophages.
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