Controlled Anchoring of Iron Oxide Nanoparticles on Polymeric Nanofibers: Easy Access to Core@Shell Organic–Inorganic Nanocomposites for Magneto-Scaffolds
Résumé
Composites combining superparamagnetic iron oxide nanoparticles (SPIONs) and polymers are
largely present in modern (bio)materials. However, while SPIONs embedded in polymer matrices
are classically reported, the mechanical and degradation properties of the polymer scaffold are
impacted by the SPIONs. Therefore, the controlled anchoring of SPIONs onto polymer surfaces is
still a major challenge. Herein, we propose an efficient strategy for the direct and uniform
anchoring of SPIONs on the surface of functionalized-polylactide (PLA) nanofibers via a simple
free ligand exchange procedure to design PLA@SPIONs core@shell nanocomposites. The
resulting PLA@SPIONs hybrid biomaterials are characterized by electron microscopy (SEM and
TEM) and EDXS analysis, to probe the morphology and detect elements present at the
organic/inorganic interface, respectively. A monolayer of SPIONs with a complete and
homogeneous coverage is observed on the surface of PLA nanofibers. Magnetization experiments
show that magnetic properties of the nanoparticles are well-preserved after their grafting on the
PLA fibers and that the size of the nanoparticles does not change. The absence of cytotoxicity,
combined with a high sensitivity of detection in MRI both in vitro and in vivo make these hybrid
nanocomposites attractive for the development of magnetic biomaterials for biomedical
applications.
Domaines
Chimie de coordination
Fichier principal
Awada - ACS Applied Materials Interfaces 2019.pdf (982.87 Ko)
Télécharger le fichier
Awada - ACS Applied Materials Interfaces 2019 - sup data.pdf (1.79 Mo)
Télécharger le fichier
| Origine | Fichiers produits par l'(les) auteur(s) |
|---|