Assessing autophagy in sciatic nerves of a rat model that develops inflammatory autoimmune peripheral neuropathies - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Cells Année : 2017

Assessing autophagy in sciatic nerves of a rat model that develops inflammatory autoimmune peripheral neuropathies

Résumé

The rat sciatic nerve has attracted widespread attention as an excellent model system for studying autophagy alterations in peripheral neuropathies. In our laboratory, we have developed an original rat model, which we used currently in routine novel drug screening and to evaluate treatment strategies for chronic inflammatory demyelinating polyneuropathy (CIDP) and other closely related diseases. Lewis rats injected with the S-palmitoylated P0(180-199) peptide develop a chronic, sometimes relapsing-remitting type of disease. Our model fulfills electrophysiological criteria of demyelination with axonal degeneration, confirmed by immunohistopathology and several typical features of CIDP. We have set up a series of techniques that led us to examine the failures of autophagy pathways in the sciatic nerve of these model rats and to follow the possible improvement of these defects after treatment. Based on these newly introduced methods, a novel area of investigation is now open and will allow us to more thoroughly examine important features of certain autophagy pathways occurring in sciatic nerves.
Fichier principal
Vignette du fichier
islandora_84554.pdf (2.99 Mo) Télécharger le fichier
Origine : Fichiers éditeurs autorisés sur une archive ouverte
Loading...

Dates et versions

hal-02347241 , version 1 (24-02-2020)

Identifiants

Citer

Susana Brun, Nicolas Schall, Hélène Jeltsch-David, Jerome De Seze, Sylviane Muller. Assessing autophagy in sciatic nerves of a rat model that develops inflammatory autoimmune peripheral neuropathies. Cells, 2017, 6 (3), pp.30. ⟨10.3390/cells6030030⟩. ⟨hal-02347241⟩
20 Consultations
36 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More