Unguiculins A-C: cytotoxic bis-guanidine alkaloids from the French Polynesian sponge, Monanchora n. sp - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Natural Product Research Année : 2018

Unguiculins A-C: cytotoxic bis-guanidine alkaloids from the French Polynesian sponge, Monanchora n. sp

Résumé

Two new acyclic bis-guanidine alkaloids, unguiculins B-C (2–3), were isolated from a French Polynesian sponge Monanchora n. sp. together with the known compound unguiculin A (1). Their structures were established by spectroscopic data interpretation and comparison with the literature. Unguiculins A-C displayed antiproliferative and cytotoxic efficacy against several human cancer cells with IC50 values in the micromolar range.

Dates et versions

hal-02339610 , version 1 (30-10-2019)

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Amr El-Demerdash, Céline Moriou, Marie-Thérèse Martin, Sylvain Petek, Cécile Debitus, et al.. Unguiculins A-C: cytotoxic bis-guanidine alkaloids from the French Polynesian sponge, Monanchora n. sp. Natural Product Research, 2018, 32 (13), pp.1512-1517. ⟨10.1080/14786419.2017.1385011⟩. ⟨hal-02339610⟩
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