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Article Dans Une Revue Sleep and Biological Rhythms Année : 2013

Brainstem structures involved in rapid eye movement sleep behavior disorder

Résumé

Rapid eye movement (REM) sleep behavior disorder (RBD) is a parasomnia characterized by the loss of muscle atonia during paradoxical (REM) sleep (PS). The neuronal dysfunctions responsible for RBD are not known. In the present review, we propose an updated integrated model of the mechanisms responsible for PS and explore different hypotheses explaining RBD. We propose that RBD appears based on a specific degeneration of PS-on glutamatergic neurons localized in the caudal pontine sublaterodorsal tegmental nucleus or the glycinergic/GABAergic premotoneurons localized in the medullary ventral gigantocellular reticular nucleus.

Dates et versions

hal-02339497 , version 1 (30-10-2019)

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Pierre-Hervé Luppi, Clément Olivier, Patrice Fort. Brainstem structures involved in rapid eye movement sleep behavior disorder. Sleep and Biological Rhythms, 2013, 11 (9-4), ⟨10.1111/j.1479-8425.2012.00544.x⟩. ⟨hal-02339497⟩
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