Endemic Plants: From Design to a New Way of Smart Hybrid Nanomaterials for Green Nanomedicine Applications
Résumé
In the present study, gold nanoparticles (AuNPs) were successfully developed by green synthesis using a strong antioxidant Quercetin (Q) known as a bioreducing agent, in the presence of Hubertia ambavilla extract plant (G) in order to form hybrid green gold nanoparticles (GQAuNPs). GQAuNPs were characterized by several Spectroscopic techniques (TEM, Raman and UV-Vis spectroscopies) to understand their physicochemical and biological properties. The average particle size was found to be around 20 nm, and corresponding average zeta potential value is −19 mV suggesting a high stability of GQAuNPs. The large negative potential value could be due to the capping of polyphenolic constituents present in the plant extract. For therapeutic intentions, we propose the important part of GQAuNPs in the hyperthermia treatment of pancreatic cancer through preliminary study based on temperature effect onto colloidal solutions under specific experimental conditions. This study, bringing a green chemical approach, will take up a meaningful, position in the field of nanomedicine, with innovative views for the development of complex- drugs and active targeting in cancer therapy.
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