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Article Dans Une Revue Science Advances Année : 2019

Synthetic self-assembling ADDomer platform for highly efficient vaccination by genetically encoded multiepitope display

Frédéric Garzoni
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Christopher Woods
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Christiane Schaffitzel
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Pascal Fender

Résumé

Self-assembling virus-like particles represent highly attractive tools for developing next-generation vaccines and protein therapeutics. We created ADDomer, an adenovirus-derived multimeric protein-based self-assembling nanoparticle scaffold engineered to facilitate plug-and-play display of multiple immunogenic epitopes from pathogens. We used cryo-electron microscopy at near-atomic resolution and implemented novel, cost-effective, high-performance cloud computing to reveal architectural features in unprecedented detail. We analyzed ADDomer interaction with components of the immune system and developed a promising first-in-kind ADDomer-based vaccine candidate to combat emerging Chikungunya infectious disease, exemplifying the potential of our approach.
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Dates et versions

hal-02333174 , version 1 (28-10-2019)

Identifiants

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Charles Vragniau, Joshua Bufton, Frédéric Garzoni, Emilie Stermann, Fruzsina Rabi, et al.. Synthetic self-assembling ADDomer platform for highly efficient vaccination by genetically encoded multiepitope display. Science Advances , 2019, 5 (9), pp.eaaw2853. ⟨10.1126/sciadv.aaw2853⟩. ⟨hal-02333174⟩
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