A review on conotoxins targeting ion channels and acetylcholine receptors of the vertebrate neuromuscular junction. - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Acta physiologica, pharmacologica et therapeutica latinoamericana : órgano de la Asociación Latinoamericana de Ciencias Fisiológicas y [de] la Asociación Latinoamericana de Farmacología Année : 1999

A review on conotoxins targeting ion channels and acetylcholine receptors of the vertebrate neuromuscular junction.

Résumé

In this article we present an overview of some peptides extracted and purified from the venom of marine snails of the genus Conus. These active peptides named conotoxins can be used as research tools to target voltage-gated ion channels as well as ligand-gated receptors. Because of their relatively small size, conotoxins can be chemically synthesized and made widely available. In this review we focus on conotoxins that target voltage-sensitive sodium channels, voltage-dependent calcium channels and nicotinic acetylcholine receptors of the vertebrate neuromuscular junction. Emphasis is given on summarizing our current knowledge of their primary structure and their specific pharmacological actions at the pre- and the post-synaptic level of the neuromuscular junction. Evidence is presented for conotoxins that discriminate between pre- and post-synaptic voltage-gated sodium channels. Among these peptides, the mu-conotoxin family is well characterized by its ability to block selectively sodium channels in skeletal muscle fibres without affecting axonal and nerve terminal Na+ channels. Furthermore, new conotoxins like Conus consors toxin (CcTx) and conotoxin EVIA selectively target Na+ channels in axons and nerve terminals without affecting skeletal muscle fibres. omega-conotoxins known as highly potent and selective blockers of voltage-sensitive calcium channels have proven to be valuable in determining the roles of the various subtypes of channels involved in acetylcholine release from motor nerve endings. Finally, Conus peptides which act at muscle nicotinic acetylcholine receptors constitute the most extensive characterized family of conopeptides that exhibit sequence similarity, different structural motifs and surprising diversity in their competitive and non-competitive actions.
Fichier non déposé

Dates et versions

hal-02330478 , version 1 (24-10-2019)

Identifiants

  • HAL Id : hal-02330478 , version 1
  • PUBMED : 10797869

Citer

P. Favreau, F. Le Gall, Evelyne Benoit, J. Molgó. A review on conotoxins targeting ion channels and acetylcholine receptors of the vertebrate neuromuscular junction.. Acta physiologica, pharmacologica et therapeutica latinoamericana : órgano de la Asociación Latinoamericana de Ciencias Fisiológicas y [de] la Asociación Latinoamericana de Farmacología, 1999, 49 (4), pp.257-67. ⟨hal-02330478⟩

Collections

CNRS NBCM
25 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More