Parameter estimation to study the immediate impact of aortic cross-clamping using reduced order models - Archive ouverte HAL Accéder directement au contenu
Pré-Publication, Document De Travail Année : 2019

Parameter estimation to study the immediate impact of aortic cross-clamping using reduced order models

Maria Teresa Politi
  • Fonction : Auteur
Juan Manuel Fernández
  • Fonction : Auteur
Arthur R Ghigo
  • Fonction : Auteur
Julien Gaudric
  • Fonction : Auteur
S A Wray
  • Fonction : Auteur
J.-B Lagaert
  • Fonction : Auteur
Ricardo Armentano
  • Fonction : Auteur
Claudia Capurro
  • Fonction : Auteur
J M Fullana
  • Fonction : Auteur
Pierre-Yves Lagrée

Résumé

Aortic cross-clamping is a common strategy during vascular surgery, however its instantaneous impact on the distribution of pressure and flow in the arterial network is unknown. We therefore developed two numerical models to investigate the immediate impact of aortic clamping on the mechanical properties of the human vessels. To assess the validity of the models, we recorded continuous invasive pressure signals during aneurysm repair surgery immediately before and after clamping. The first model is a zero-dimensional (0D) three-element Windkessel model which we coupled to a parameter estimation method with a gradient-based algorithm to identify patient-specific parameters such as resistance and compliance. We found a 10% increase in total resistance and 20% decrease in total compliance with clamping. The second model is a 9-artery network corresponding to an average human body in which we solved the one-dimensional (1D) blood flow equations. We developed a technique to construct the 1D network to match the global mechanical properties of the Windkessel model. We found that with such definition, the 1D model is sufficient to predict and reproduce numerically the impact of surgical clamping on the morphology of pressure waves. Both models gave an accurate description of the pressure wave with a high correlation (R 2 > 0.95) between experimental and simulated blood pressure data.
Fichier principal
Vignette du fichier
Main_document.pdf (840.36 Ko) Télécharger le fichier
Loading...

Dates et versions

hal-02328189 , version 1 (23-10-2019)

Identifiants

  • HAL Id : hal-02328189 , version 1

Citer

Jeanne Ventre, Maria Teresa Politi, Juan Manuel Fernández, Arthur R Ghigo, Julien Gaudric, et al.. Parameter estimation to study the immediate impact of aortic cross-clamping using reduced order models. 2019. ⟨hal-02328189⟩
46 Consultations
117 Téléchargements

Partager

Gmail Facebook X LinkedIn More