Cm$^{3+}$/Eu$^{3+}$ induced structural, mechanistic and functional implications for calmodulin - Archive ouverte HAL Access content directly
Journal Articles Phys.Chem.Chem.Phys. Year : 2019

Cm$^{3+}$/Eu$^{3+}$ induced structural, mechanistic and functional implications for calmodulin

Björn Drobot
  • Function : Author
Moritz Schmidt
  • Function : Author
Yuji Mochizuki
  • Function : Author
Takaya Abe
  • Function : Author
Koji Okuwaki
  • Function : Author
Sven Falke
  • Function : Author
Sergey A. Samsonov
  • Function : Author
Yuto Komeiji
  • Function : Author
Christian Betzel
  • Function : Author
Thorsten Stumpf
  • Function : Author
Johannes Raff
  • Function : Author
Satoru Tsushima
  • Function : Author

Abstract

Trivalent lanthanide and actinide can strongly bind to calmodulin (CaM). The global structure of Ln/An-bound CaM were found to be similar to Ca-CaM but the local environment around Ln/An is distorted giving less structural rigidity to Ln/An-CaM
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Dates and versions

hal-02327781 , version 1 (23-10-2019)

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Björn Drobot, Moritz Schmidt, Yuji Mochizuki, Takaya Abe, Koji Okuwaki, et al.. Cm$^{3+}$/Eu$^{3+}$ induced structural, mechanistic and functional implications for calmodulin. Phys.Chem.Chem.Phys., 2019, 21 (38), pp.21213-21222. ⟨10.1039/C9CP03750K⟩. ⟨hal-02327781⟩
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