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Article Dans Une Revue Bioscience, Biotechnology and Biochemistry Année : 2018

Ets-1 interacts through a similar binding interface with Ku70 and Poly (ADP-Ribose) Polymerase-1

Résumé

The Ets-1 transcription factor plays an important role in various physiological and pathological processes. These diverse roles of Ets-1 are likely to depend on its interaction proteins. We have previously showed that Ets-1 interacted with DNA-dependent protein kinase (DNA-PK) complex including its regulatory subunits, Ku70 and Ku86 and with poly (ADP-ribose) polymerase-1 (PARP-1). In this study, the binding domains for the interaction between Ets-1 and these proteins were reported. We demonstrated that the interaction of Ets-1 with DNA-PK was mediated through the Ku70 subunit and was mapped to the C-terminal region of Ets-1 and the C-terminal part of Ku70 including SAP domain. The interactive domains between Ets-1 and PARP-1 have been mapped to the C-terminal region of Ets-1 and the BRCA1 carboxy-terminal (BRCT) domain of PARP-1. The results presented in this study may advance our understanding of the functional link between Ets-1 and its interaction partners, DNA-PK and PARP-1.
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Dates et versions

hal-02327208 , version 1 (22-10-2019)

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Souhaila Choul-Li, Arnaud Legrand, Baptiste Bidon, Dorothée Vicogne, Vincent Villeret, et al.. Ets-1 interacts through a similar binding interface with Ku70 and Poly (ADP-Ribose) Polymerase-1. Bioscience, Biotechnology and Biochemistry, 2018, 82 (10), pp.1753-1759. ⟨10.1080/09168451.2018.1484276⟩. ⟨hal-02327208⟩
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