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Article Dans Une Revue Frontiers in Immunology Année : 2018

Mycobacterial Phenolic Glycolipids Selectively Disable TRIF-Dependent TLR4 Signaling in Macrophages

Résumé

PGL-1 as a model, we found that PGLs dampen the toll-like receptor (TLR)4 signaling pathway, with macrophage exposure to PGLs leading to significant reduction in TIR-domain-containing adapter-inducing interferon-β (TRIF) protein level. PGL-driven decrease in TRIF operated posttranscriptionally and independently of Src-family tyrosine kinases, lysosomal and proteasomal degradation. It resulted in the defective production of TRIF-dependent IFN-β and CXCL10 in TLR4-stimulated macrophages, in addition to iNOS. Our results unravel a mechanism by which PGLs hijack both the bactericidal and inflammatory responses of host macrophages. Moreover, they identify TRIF as a critical node in the crosstalk between CR3 and TLR4.

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Immunité innée
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hal-02323696 , version 1 (21-10-2019)

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Reid Oldenburg, Véronique Mayau, Jacques Prandi, Ainhoa Arbues, Catherine Astarie-Dequeker, et al.. Mycobacterial Phenolic Glycolipids Selectively Disable TRIF-Dependent TLR4 Signaling in Macrophages. Frontiers in Immunology, 2018, 9, 12 p. ⟨10.3389/fimmu.2018.00002⟩. ⟨hal-02323696⟩
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