From a clinical observation of chronic wound microbiology to the elaboration of an anti-biofilm dressing: The PANSaBIO project strategy - Archive ouverte HAL Access content directly
Journal Articles Innovation and Research in BioMedical engineering Year : 2014

From a clinical observation of chronic wound microbiology to the elaboration of an anti-biofilm dressing: The PANSaBIO project strategy

Abstract

The PANSaBIO project aims to evaluate the prevalence of biofilms on a large panel of chronic wounds (more than 100 samples) and relate its presence to the type and history of the wound and its microbiology. A large file computing all the data is under construction. Moreover, several strategies to prepare an innovative anti-biofilm dressing have been developed. On one hand, antimicrobial peptides were grafted to gelatin; the modified protein can be used to prepare an active dressing. Second, various antiseptics were entrapped in a gelatin gel. An adaptation was necessary to obtain the convenient mechanical properties of the gel. Then this preparation was turned to a dressing. A first generation of dressings efficient against biofilms of Pseudomonas aeruginosa and Staphylococus aureus is available today.
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hal-02323048 , version 1 (21-10-2019)

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E. Lefebvre, I. Lequeux, C. Vighetto, I. Fromantin, P. Thébault, et al.. From a clinical observation of chronic wound microbiology to the elaboration of an anti-biofilm dressing: The PANSaBIO project strategy. Innovation and Research in BioMedical engineering, 2014, 35 (2), pp.77-81. ⟨10.1016/j.irbm.2014.02.003⟩. ⟨hal-02323048⟩
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