Ligand-Controlled Regiodivergent Hydroformylation of Ynamides: A Stereospecific and Regioselective Access to 2- and 3-Aminoacroleins - Archive ouverte HAL Access content directly
Journal Articles Organic Letters Year : 2019

Ligand-Controlled Regiodivergent Hydroformylation of Ynamides: A Stereospecific and Regioselective Access to 2- and 3-Aminoacroleins

Abstract

The rhodium-catalyzed hydroformylation of ynamides is described and give selectively access to 2-or 3-aminoacrolein derivatives. The regioselectivity of this carbonylation can be completely controlled at will thanks to the nature of the ligand used. This represent the first example of regiodivergent alkyne hy-droformylation. The influence of the substituents on the differ-ent positions of the ynamide has been investigated and it ap-peared that this reaction is tolerant to a wide range of functional groups
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hal-02322712 , version 1 (05-11-2020)

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Patrick Wagner, Morgan Donnard, Nicolas Girard. Ligand-Controlled Regiodivergent Hydroformylation of Ynamides: A Stereospecific and Regioselective Access to 2- and 3-Aminoacroleins. Organic Letters, 2019, ⟨10.1021/acs.orglett.9b03566⟩. ⟨hal-02322712⟩
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