A Fused Hexacyclic Ring System: Diastereoselective Polycyclization of 2,4-Dienals through an Interrupted iso-Nazarov Reaction
Résumé
An unprecedented iso-Nazarov initiated domino polycyclization from readily available 2,4-dienals and cyclic ,unsaturated imines is reported. This Brønsted acid-promoted reaction enables the concomitant formation of four bonds, three cycles and four contiguous stereogenic centers to yield elaborated structures in a single operation. A range of fused hexacyclic molecules is obtained in a highly diastereoselective manner.
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