N , N′ -Disubstituted Barbituric Acid: A Versatile and Modular Multifunctional Platform for Obtaining β- C -Glycoconjugates from Unprotected Carbohydrates in Water
Résumé
Direct access to non-hydrolyzable glycoconjugates is highly mandatory for stabilizing their intrinsic biological or physical-chemistry properties in the surrounding environment. Here, a simple and versatile approach for the preparation of multifunctional clickable-C-glycoconjugates has been developed. Readily accessible N,N′-disubstituted barbituric acids have been synthesized and ligated in water to the reducing end
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