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Article Dans Une Revue Reproductive BioMedicine Online Année : 2017

Anti-Müllerian hormone concentrations and parity in fertile women: the model of oocyte donors

Résumé

In France until the end of 2015, oocyte donors must have had at least one child and be aged 18-37 years. This population of fertile women was selected to examine whether serum anti-Müllerian hormone (AMH) concentration could be a reliable correlate of spontaneous pregnancy in women who had proven their fertility before. A cohort of 217 women followed between 2009 and 2015 for oocyte donation at the University Hospital of Lille comprised this retrospective study. In these egg donors, aged 20-37 (median: 32 years), the median serum AMH level was 22 pmol/l (5-95th percentiles: 4.9-61.8). No significant correlation was found between serum AMH level and the number of children or the youngest child's age. Among the 32 women with AMH <10 pmol/l, 9 and 3 were less than 30 and 25 years old, respectively. Six women (2.8%) had undetectable serum AMH, i.e. <3 pmol/l. In conclusion, serum AMH level measured in this fertile female cohort showed too much variability to be a good fertility index. Assessment of serum AMH should only be discussed for patients at risk of ovarian failure.
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Dates et versions

hal-02315032 , version 1 (14-10-2019)

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Sophie Catteau-Jonard, Marie Roux, Agathe Dumont, Anne-Sophie Delesalle, Geoffroy Robin, et al.. Anti-Müllerian hormone concentrations and parity in fertile women: the model of oocyte donors. Reproductive BioMedicine Online, 2017, 34 (5), pp.541-545. ⟨10.1016/j.rbmo.2017.02.010⟩. ⟨hal-02315032⟩
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