MrIC, a Novel α-Conotoxin Agonist in the Presence of PNU at Endogenous α7 Nicotinic Acetylcholine Receptors - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Biochemistry Année : 2013

MrIC, a Novel α-Conotoxin Agonist in the Presence of PNU at Endogenous α7 Nicotinic Acetylcholine Receptors

Irina Vetter
Nikita Abraham
  • Fonction : Auteur
Nayara B Emidio
  • Fonction : Auteur
Marco Inserra
  • Fonction : Auteur
Swetha S Murali
  • Fonction : Auteur
Paul F Alewood
  • Fonction : Auteur
Richard J Lewis
  • Fonction : Auteur

Résumé

α-Conotoxins are competitive antagonists of nicotinic acetylcholine receptors (nAChRs). Their high selectivity and affinity for the various subtypes of nAChRs have led to significant advances in our understanding of the structure and function of these key ion channels. Here we report the discovery of a novel 4/7 α-conotoxin, MrIC from the venom duct of Conus marmoreus, which acts as an agonist at the endogenous human α7 nAChR in SH-SY5Y cells pretreated with PNU120596 (PNU). This unique agonist activity of MrIC at α7 nAChRs may guide the development of novel α7 nAChR modulators.
Fichier non déposé

Dates et versions

hal-02306950 , version 1 (08-10-2019)

Identifiants

Citer

Ai-Hua Jin, Irina Vetter, Sébastien Dutertre, Nikita Abraham, Nayara B Emidio, et al.. MrIC, a Novel α-Conotoxin Agonist in the Presence of PNU at Endogenous α7 Nicotinic Acetylcholine Receptors. Biochemistry, 2013, 53 (1), pp.1-3. ⟨10.1021/bi400882s⟩. ⟨hal-02306950⟩
17 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More