Structure of the O-Glycosylated Conopeptide CcTx from Conus consors Venom - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Chemistry - A European Journal Année : 2013

Structure of the O-Glycosylated Conopeptide CcTx from Conus consors Venom

Résumé

The glycopeptide CcTx, isolated from the venom of the piscivorous cone snail Conus consors, belongs to the κA-family of conopeptides. These toxins elicit excitotoxic responses in the prey by acting on voltage-gated sodium channels. The structure of CcTx, a first in the κA-family, has been determined by high-resolution NMR spectroscopy together with the analysis of its O-glycan at Ser7. A new type of glycopeptide O-glycan core structure, here registered as core type 9, containing two terminal L-galactose units {α-L-Galp-(1→4)-α-D-GlcpNAc-(1→6)-[α-L-Galp-(1→2)-β-D-Galp-(1→3)-]α-D-GalpNAc-(1→O)}, is highlighted. A sequence comparison to other putative members of the κA-family suggests that O-linked glycosylation might be more common than previously thought. This observation alone underlines the requirement for more careful and in-depth investigations into this type of post-translational modification in conotoxins.

Dates et versions

hal-02306937 , version 1 (08-10-2019)

Identifiants

Citer

Henry G Hocking, Gerrit J Gerwig, Sébastien Dutertre, Aude Violette, Philipe Favreau, et al.. Structure of the O-Glycosylated Conopeptide CcTx from Conus consors Venom. Chemistry - A European Journal, 2013, 19 (3), pp.870-879. ⟨10.1002/chem.201202713⟩. ⟨hal-02306937⟩
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