Study of release kinetics of small and high molecular weight substances dispersed into spray-dried ethylcellulose microspheres - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Journal of Controlled Release Année : 2002

Study of release kinetics of small and high molecular weight substances dispersed into spray-dried ethylcellulose microspheres

Résumé

Spray-dried ethylcellulose microspheres were used as matrices for the encapsulation of a fungal lactase and/or small paramagnetic probes (Tempol or Tempo). Their dissolution in water was studied. Kinetics fitted with the model Q = kt(n) of Korsemeyer et al. [Int. J. Pharm. 15 (1983) 25] exhibited a non-Fickian diffusion. The calculated diffusional exponent (n) values were near 0.26 whatever the encapsulated probes. The release rates (k) were only slightly different for paramagnetic probes and lactase. This result indicated that the probes' release mechanisms are not diffusion controlled. Other factors such as matrix porosity and probe solubility in the matrix and in water could influence the probes' release rate.

Dates et versions

hal-02303213 , version 1 (02-10-2019)

Identifiants

Citer

Nicolas Grattard, Marc Pernin, Bernard Marty, Gaëlle Roudaut, Dominique Champion, et al.. Study of release kinetics of small and high molecular weight substances dispersed into spray-dried ethylcellulose microspheres. Journal of Controlled Release, 2002, 84 (3), pp.125-135. ⟨10.1016/s0168-3659(02)00260-2⟩. ⟨hal-02303213⟩

Collections

ENSBANA
23 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More