ETSI TS 103 327 V1.1.1. The present document describes and specifies the high level infrastructure, its building blocks and associated APIs providing interoperability management solutions for SmartBAN. The architecture described in the present document also enables generic interaction and access to BAN data and entities, and thus paves the way to interoperability (networks and syntactic interoperability). Since the SmartBAN reference architecture specified and formatized in the present document fully relies on SmartBAN open semantic data model and corresponding ontologies as already standardized in [1], it therefore also addresses data and semantic interoperability. The present document is applicable to a BAN and/or a SmartBAN comprising wearable sensors/actuators devices, a relay/coordinator device and a Hub. The relay/Coordinator and the Hub functionalities may be handled by a single device or by two distinct devices. The present document is also addressing syntactic interoperability by defining unified data transfer and message formats