Immune Conversion of Tumor Microenvironment by Oncolytic Viruses: The Protoparvovirus H-1PV Case Study - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Frontiers in Immunology Année : 2019

Immune Conversion of Tumor Microenvironment by Oncolytic Viruses: The Protoparvovirus H-1PV Case Study

Résumé

Cancer cells utilize multiple mechanisms to evade and suppress anticancer immune responses creating a "cold" immunosuppressive tumor microenvironment. Oncolytic virotherapy is emerging as a promising approach to revert tumor immunosuppression and enhance the efficacy of other forms of immunotherapy. Growing evidence indicates that oncolytic viruses (OVs) act in a multimodal fashion, inducing immunogenic cell death and thereby eliciting robust anticancer immune responses. In this review, we summarize information about OV-mediated immune conversion of the tumormicroenvironment. As a case study we focus on the rodent protoparvovirus H-1PV and its dual role as an oncolytic and immunemodulatory agent. Potential strategies to improve H-1PV anticancer efficacy are also discussed.
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Dates et versions

hal-02273519 , version 1 (05-10-2020)

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Antonio Marchini, Laurent Daeffler, Vitaly Pozdeev, Assia Angelova, Jean Rommelaere. Immune Conversion of Tumor Microenvironment by Oncolytic Viruses: The Protoparvovirus H-1PV Case Study. Frontiers in Immunology, 2019, 10, ⟨10.3389/fimmu.2019.01848⟩. ⟨hal-02273519⟩
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