The oxidation of din -propyl-ether (DPE), was studied in a jet-stirred reactor. Fuel-lean, stoichiometric and fuel-rich mixtures (phi = 0.5-4) were oxidized at a constant fuel mole fraction of 1000 ppm, at temperatures ranging from 470 to 1160 K, at 10 atm, and constant residence time of 700 ms. The mole fraction profiles obtained through sonic probe sampling, were analyzed by gas chromatography and Fourier Transform Infrared spectrometry. As was the case in our previous studies on ethers (diethyl ether and din -butyl ether), the carbon neighboring the ether group was found to be the most favorable site for H-abstraction reactions and the chemistry of the corresponding fuel radical drives the overall reactivity. The fuel concentration profiles indicated strong low-temperature chemistry. A kinetic sub-mechanism is developed based on similar rules as the other two symmetric ethers investigated. The proposed mechanism shows good performances in representing the present experimental data, nevertheless, more data such as atmospheric pressure speciation will be needed in order to better interpret the kinetic behavior of DPE.