The Needs for Developing Experiments on Reservoirs in Hantavirus Research: Accomplishments, Challenges and Promises for the Future - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue (Article De Synthèse) Viruses Année : 2019

The Needs for Developing Experiments on Reservoirs in Hantavirus Research: Accomplishments, Challenges and Promises for the Future

Résumé

Due to their large geographic distribution and potential high mortality rates in human infections, hantaviruses constitute a worldwide threat to public health. As such, they have been the subject of a large array of clinical, virological and eco-evolutionary studies. Many experiments have been conducted in vitro or on animal models to identify the mechanisms leading to pathogenesis in humans and to develop treatments of hantavirus diseases. Experimental research has also been dedicated to the understanding of the relationship between hantaviruses and their reservoirs. However, these studies remain too scarce considering the diversity of hantavirus/reservoir pairs identified, and the wide range of issues that need to be addressed. In this review, we present a synthesis of the experimental studies that have been conducted on hantaviruses and their reservoirs. We aim at summarizing the knowledge gathered from this research, and to emphasize the gaps that need to be filled. Despite the many difficulties encountered to carry hantavirus experiments, we advocate for the need of such studies in the future, at the interface of evolutionary ecology and virology. They are critical to address emerging areas of research, including hantavirus evolution and the epidemiological consequences of individual variation in infection outcomes.
Fichier principal
Vignette du fichier
Publis19-cbgp-021_madrières_needs.pdf (308.61 Ko) Télécharger le fichier
Origine Accord explicite pour ce dépôt
Licence
Loading...

Dates et versions

hal-02271482 , version 1 (26-08-2019)

Licence

Identifiants

Citer

Sarah Madrières, Guillaume Castel, Séverine Murri, Johann Vulin, Philippe Marianneau, et al.. The Needs for Developing Experiments on Reservoirs in Hantavirus Research: Accomplishments, Challenges and Promises for the Future. Viruses, 2019, 11 (7), pp.664. ⟨10.3390/v11070664⟩. ⟨hal-02271482⟩
41 Consultations
47 Téléchargements

Altmetric

Partager

Gmail Mastodon Facebook X LinkedIn More