Contribution to PNA-RNA Chimera Synthesis: One-Pot Microwave-Assisted Ugi Reaction to Obtain Dimeric Building Blocks - Archive ouverte HAL Access content directly
Journal Articles European Journal of Organic Chemistry Year : 2017

Contribution to PNA-RNA Chimera Synthesis: One-Pot Microwave-Assisted Ugi Reaction to Obtain Dimeric Building Blocks

Abstract

We report a solution-phase synthesis of dimeric PNA-RNA (PNA = peptide nucleic acid) building blocks by using a microwave-assisted Ugi four-component reaction. A mixture of a functionalized amine, a carboxymethyl nucleobase, para-formaldehyde, and N4,2'-O,3'-O-tribenzoyl-5'-deoxy-5'-isocyanocytidine generates the dimeric chimeras in one step. The method is simple, and gives rapid access (5 min) to diversity, as exemplified by the products described here.
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hal-02197216 , version 1 (30-07-2019)

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Reuben Ovadia, Clémence Mondielli, Jean-Jacques Vasseur, Carine Baraguey, Karine Alvarez. Contribution to PNA-RNA Chimera Synthesis: One-Pot Microwave-Assisted Ugi Reaction to Obtain Dimeric Building Blocks. European Journal of Organic Chemistry, 2017, 2017 (3), pp.469-475. ⟨10.1002/ejoc.201601190⟩. ⟨hal-02197216⟩
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