The impact of sugar-sweetened beverage intake on rat cardiac function - Archive ouverte HAL Access content directly
Journal Articles Heliyon Year : 2019

The impact of sugar-sweetened beverage intake on rat cardiac function

N. Driescher
  • Function : Author
D. E. Joseph
  • Function : Author
V. R. Human
  • Function : Author
E. Ojuka
  • Function : Author
N. Hadebe
  • Function : Author
D. Bester
  • Function : Author
J. L. Marnewick
  • Function : Author
S. Lecour
  • Function : Author
A. Lochner
  • Function : Author
M. F. Essop
  • Function : Author

Abstract

Aims: Although there is evidence linking sugar-sweetened beverage (SSB) intake with the development of cardio-metabolic diseases, the underlying mechanisms remain unclear. The current study therefore evaluated the effects of SSB consumption by establishing a unique in-house in vivo experimental model. Main methods: Male Wistar rats were divided into two groups: a) one consuming a popular local SSB (SSB- Jive), and b) a control group (Control-water) for a period of three and six months (n = 6 per group), respectively. Rats were gavaged on a daily basis with an experimental dosage amounting to half a glass per day (in human terms) (SSB vs. water). Cardiac function was assessed at baseline (echocardiography) and following ex vivo ischemia-reperfusion of the isolated perfused working rat heart. Oral glucose tolerance tests and mitochondrial respiratory analyses were also performed. In addition, the role of non-oxidative glucose pathways (NOGPs), i.e. the polyol pathway, hexosamine biosynthetic pathway (HBP) and PKC were assessed. Key findings: These data show that SSB intake: a) resulted in increased weight gain, but did not elicit major effects in terms of insulin resistance and cardiac function after three and six months, respectively; b) triggered myocardial NOGP activation after three months with a reversion after six months; and c) resulted in some impairment in mitochondrial respiratory capacity in response to fatty acid substrate supply after six months. Significance: SSB intake did not result in cardiac dysfunction or insulin resistance. However, early changes at the molecular level may increase risk in the longer term.

Dates and versions

hal-02195265 , version 1 (26-07-2019)

Identifiers

Cite

N. Driescher, D. E. Joseph, V. R. Human, E. Ojuka, M. Cour, et al.. The impact of sugar-sweetened beverage intake on rat cardiac function. Heliyon, 2019, 5 (3), pp.e01357. ⟨10.1016/j.heliyon.2019.e01357⟩. ⟨hal-02195265⟩
10 View
0 Download

Altmetric

Share

Gmail Facebook X LinkedIn More