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Article Dans Une Revue Transcription Année : 2017

Toward understanding of the mechanisms of Mediator function in vivo: Focus on the preinitiation complex assembly

Résumé

Mediator is a multisubunit complex conserved in eukaryotes that plays an essential coregulator role in RNA polymerase (Pol) II transcription. Despite intensive studies of the Mediator complex, the molecular mechanisms of its function in vivo remain to be fully defined. In this review, we will discuss the different aspects of Mediator function starting with its interactions with specific transcription factors, its recruitment to chromatin and how, as a coregulator, it contributes to the assembly of transcription machinery components within the preinitiation complex (PIC) in vivo and beyond the PIC formation.

Dates et versions

hal-02194247 , version 1 (25-07-2019)

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Thomas Eychenne, Michel Werner, Julie Soutourina. Toward understanding of the mechanisms of Mediator function in vivo: Focus on the preinitiation complex assembly. Transcription, 2017, 8 (5), pp.328--342. ⟨10.1080/21541264.2017.1329000⟩. ⟨hal-02194247⟩
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