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Article Dans Une Revue Oncogene Année : 1995

TGF-beta 1 and cAMP attenuate cyclin A gene transcription via a cAMP responsive element through independent pathways

Résumé

Transforming growth factor beta (TGF-beta) is a potent inhibitor of the proliferation of many cell lines. The expression of Cyclin A is down-regulated by TGF-beta 1 in Chinese hamster lung fibroblasts and most of this effect is mediated at the transcriptional level through a cAMP-responsive element (CRE), but does not require a functional cAMP-dependent protein kinase. However, activation of the cAMP pathway in these cells gives rise to a strong inhibition of proliferation, paralleled by a down-regulation of Cyclin A promoter activity. This effect requires the integrity of the CRE, suggesting a role for CRE-binding proteins in late G1/S controls.
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Dates et versions

hal-02192662 , version 1 (24-07-2019)

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  • HAL Id : hal-02192662 , version 1
  • PUBMED : 7478551

Citer

I. Barlat, B. Henglein, A. Plet, N. Lamb, A. Fernandez, et al.. TGF-beta 1 and cAMP attenuate cyclin A gene transcription via a cAMP responsive element through independent pathways. Oncogene, 1995, 11 (7), pp.1309--18. ⟨hal-02192662⟩
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