Isomerization of Chiral Non-Racemic α-Substituted Propargylic Amines to Terminal Acetylenes
Résumé
Various α‐substituted propargylamines, prepared in three steps from (R)‐phenylglycinol, are readily isomerized at 0 °C with KAPA to form terminal acetylenic amines, without any detectable epimerization of the chiral center, as already observed for propargyl alcohols. Enantiomerically pure primary α‐substituted alkynylamines can be easily obtained in two steps after removal of the ferrocenylmethyl protective group and oxidative cleavage of the chiral appendage.
Domaines
Chimie organique
Origine : Fichiers produits par l'(les) auteur(s)
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