Natural Deep Eutectic Solvents as Agents for Improving Solubility, Stability and Delivery of Curcumin - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Pharmaceutical Research Année : 2019

Natural Deep Eutectic Solvents as Agents for Improving Solubility, Stability and Delivery of Curcumin

Résumé

Purpose: Study on curcumin dissolved in natural deep eutec-tic solvents (NADES) was aimed at exploiting their beneficial properties as drug carriers. Methods: The concentration of dissolved curcumin in NADES was measured. Simulated gastrointestinal fluids were used to determine the concentration of curcumin and quantum chemistry computations were performed for clarifying the origin of curcumin solubility enhancement in NADES. Results NADES comprising choline chloride and glycerol had the highest potential for curcumin dissolution. This system was also successfully applied as an extraction medium for obtaining curcuminoids from natural sources, as well as an effective stabilizer preventing curcumin degradation from sunlight. The solubility of curcumin in simulated gastrointes-tinal fluids revealed that the significant increase of bioavail-ability takes place in the small intestinal fluid. Conclusions Suspension of curcumin in NADES offers beneficial properties of this new liquid drug formulation starting from excreting from natural sources, through safe storage and ending on the final administration route. Therefore, there is a possibility of using a one-step process with this medium. The performed quantum chemistry computations clearly indicated the origin of the enhanced solubility of curcumin in NADES in the presence of intestinal fluids. Direct intermolecular contacts leading to hetero-molecular pairs with choline chloride and glycerol are responsible for elevating the bulk concentration of curcumin. Choline chloride plays a dominant role in the system and the complexes formed with curcumin are the most stable among all possible homo-and hetero-molecular pairs that can be found in NADES-curcumin systems.
Fichier principal
Vignette du fichier
10.1007%2Fs11095-019-2643-2.pdf (698.46 Ko) Télécharger le fichier
Origine : Publication financée par une institution
Loading...

Dates et versions

hal-02184283 , version 1 (16-07-2019)

Identifiants

Citer

Tomasz Jeliński, Maciej Przybyłek, Piotr Cysewski. Natural Deep Eutectic Solvents as Agents for Improving Solubility, Stability and Delivery of Curcumin. Pharmaceutical Research, 2019, 36 (8), ⟨10.1007/s11095-019-2643-2⟩. ⟨hal-02184283⟩
35 Consultations
254 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More