NOD2 prevents emergence of disease-predisposing microbiota - Archive ouverte HAL Access content directly
Journal Articles Gut microbes Year : 2013

NOD2 prevents emergence of disease-predisposing microbiota


The gut flora is composed of a huge number of diverse, well-adapted symbionts that interact with epithelial lining throughout the host's entire life. Not all commensals have the same ability to maintain quiescent, protective inflammation. Importantly, instability in the composition of gut microbial communities (referred to as dysbiosis) has been linked to loss of gut barrier in the context of common human illnesses with increasing socio-economic impacts, such as Crohn disease and colorectal cancer. Our recent findings suggest that disease-predisposing dysbiosis can now be intentionally manipulated by targeting the major Crohn disease-predisposing NOD2 gene. That knowledge will not only add a new dimension to the often overlooked microbiology of Crohn disease and colorectal cancer, but will also have a broad impact on biomedical sciences worldwide.

Dates and versions

hal-02180087 , version 1 (11-07-2019)



Thomas Secher, Sylvain Normand, Mathias Chamaillard. NOD2 prevents emergence of disease-predisposing microbiota. Gut microbes, 2013, 4 (4), pp.353-356. ⟨10.4161/gmic.25275⟩. ⟨hal-02180087⟩
14 View
0 Download



Gmail Facebook X LinkedIn More