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Article Dans Une Revue Heterocycles Année : 2019

Study toward an Asymmetric and Catalytic Synthesis of Koumine

Résumé

A synthetic study of koumine, a natural product with a densely functionalized and inspiring heterocyclic skeleton, was conducted by exploring a strategy of desymmetrization of 1,3-cyclohexanedione by an intramolecular vinylation reaction of an enolate under palladium catalysis to give a strained bridgehead 1,3-cyclohexanedione scaffold. In the course of the study, a domino ring expansion was discovered and developed.

Domaines

Chimie organique
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Dates et versions

hal-02179655 , version 1 (11-07-2019)

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Jacques Maddaluno, David Reyes Loya, Michaël de Paolis. Study toward an Asymmetric and Catalytic Synthesis of Koumine. Heterocycles, 2019, 99 (2), pp.1388. ⟨10.3987/COM-18-S(F)83⟩. ⟨hal-02179655⟩
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