Gold-silver catalyzed straightforward one pot synthesis of pyrano[3,4- b]pyrrol-7(1H)-ones
Résumé
Pyrano[3,4-b]pyrrol-7(1H)-one is a bicyclic structure that is rarely described in the literature but found in numerous polycyclic natural products as Lamellarins. This work presents an one-pot synthesis of pyrano[3,4-b]pyrrol-7(1H)-one substituted in 2-and 5-position. The reaction proceeds via a one-pot two steps 5-endo-dig and 6-endo-dig cyclizations catalyzed by a cationic gold complex with high regioselectivity.
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