Journal Articles CHIMIA Year : 2017

Total Syntheses of Mycolactone A/B and its Analogues for the Exploration of the Biology of Buruli Ulcer

Abstract

Buruli ulcer, classified as a neglected tropical disease by the World Health Organization, is caused by a mycobacterium which secretes a macrolidic exotoxin called mycolactone A/B. In this article, several synthetic strategies for the preparation of this toxin are discussed, highlighting the importance of total synthesis for the exploration of biological mechanism underpinning relevant human diseases.

Dates and versions

hal-02166539 , version 1 (26-06-2019)

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Sarah Saint-Auret, Anne-Caroline Chany, Virginie Casarotto, Cédric Tresse, Lise Parmentier, et al.. Total Syntheses of Mycolactone A/B and its Analogues for the Exploration of the Biology of Buruli Ulcer. CHIMIA, 2017, 71 (12), ⟨10.2533/chimia.2017.836⟩. ⟨hal-02166539⟩
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