Axonal Regrowth Through a Collagen Guidance Channel Bridging Spinal Cord to the Avulsed C6 Roots: Functional Recovery in Primates With Brachial Plexus Injury - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Journal of Neuroscience Research Année : 1998

Axonal Regrowth Through a Collagen Guidance Channel Bridging Spinal Cord to the Avulsed C6 Roots: Functional Recovery in Primates With Brachial Plexus Injury

Résumé

Intraspinal implantation of a collagen guidance channel (CGC) to promote axon regeneration was investigated in marmosets with brachial plexus injury. After avulsion of the right C5, C6 and C7 spinal roots, a CGC containing (group B) or not (group A) a nerve segment, or a nerve graft (group C), was ventro-laterally implanted into the cord to bridge the ventral horn and the avulsed C6 roots. No spinal cord dysfunction was observed following surgery. Two months later, the postop-erative flaccid paralysis of the lesioned arm improved. In five months, a normal electromyogram of the affected biceps muscle was recorded in all repaired animals. Motor evoked potentials were obtained with a mean amplitude of 13.37 ؎ 13.66 V in group A, 13.21 ؎ 5.16 V in group B and 37.14 ؎ 35.16 V in group C. The force of biceps muscle contraction was 27.33 ؎ 20.03 g (group A), 24.33 ؎ 17.03 g (group B) and 37.38 ؎ 21.70 g (group C). Retrograde tracing by horseradish peroxidase showed labelled motoneurons ipsilaterally located in the C5 and C6 ventral horn, nearby the implantation site. The mean labelled neu-rons was 32.33 ؎ 21.13, 219.33 ؎ 176.29 and 64.33 ؎ 23.54 in group A, B and C respectively. Histological analysis presented numerous myelinated and unmy-elinated regenerating axons in the implant of these animals. Statistical analysis did not show significant difference among the three repaired groups. Our results indicate that spinal neurons can regenerate through a CGC to avulsed nerve roots and induce motor recovery in primates.

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hal-02155547 , version 1 (13-06-2019)

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Citer

S Liu, N Bodjarian, O Langlois, A S Bonnard, N Boisset, et al.. Axonal Regrowth Through a Collagen Guidance Channel Bridging Spinal Cord to the Avulsed C6 Roots: Functional Recovery in Primates With Brachial Plexus Injury. Journal of Neuroscience Research, 1998, 51 (6), pp.723 - 734. ⟨10.1002/(sici)1097-4547(19980315)51:6%3C723::aid-jnr6%3E3.0.co;2-d⟩. ⟨hal-02155547⟩
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