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Article Dans Une Revue European Journal of Epidemiology Année : 2019

Stem cell replication, somatic mutations and role of randomness in the development of cancer

Résumé

An intense scientific debate has recently taken place relating to the "bad luck" hypothesis in cancer development, namely that intrinsic random, and therefore unavoidable, mutagenic events would have a predominant role in tumorigenesis. In this article we review the main contributions to this debate and explain the reasons why the claim that cancer is mostly explained by intrinsic random factors is unsupported by data and theoretical models. In support of this, we present an analysis showing that smoking-induced mutations are more predictive of cancer risk than the lifetime number of stem cell cellular divisions.
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Dates et versions

hal-02153485 , version 1 (27-01-2024)

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Citer

Vittorio Perduca, Ludmil Alexandrov, Michelle Kelly-Irving, Cyrille Delpierre, Hanane Omichessan, et al.. Stem cell replication, somatic mutations and role of randomness in the development of cancer. European Journal of Epidemiology, 2019, 34 (5), pp.439-445. ⟨10.1007/s10654-018-0477-6⟩. ⟨hal-02153485⟩
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