The marine sponge Dactylospongia metachromia (de Laubenfels, 1954) can be abundantly observed on the outer reef slope of some French Polynesian atolls. This species has for some years been the subject of scientific research in order to promote natural stocks in the field of human health. It is in particular towards the development of new drugs and cosmetic products from molecules generated by this sponge that efforts tend today. As sponges culturing can rely on their natural capacity to regenerate through the restoration of damaged fragments, a sustainable production in the context of a blue economy is conceivable. To avoid destroying wild populations while performing ecological and chemical studies, an aquaculture project assessing the mariculture potential of Dactylospongia metachromia was launched in November 2018 in Rangiroa (Tuamotu Archipelago). A regular monitoring of the installations will provide a broad panel of datasets to judge their effectiveness and the sponge subsequent acclimation. The post-harvest treatment of the new sponge generations will be aimed at extracting secondary metabolites of interest for pharmaceutical applications.