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Article Dans Une Revue International Journal of Peptide and Protein Research Année : 1985

Solid phase synthesis of two cholera toxin B subunit antigens.

A. Delmas

Résumé

The 30-50 and 50-75 sequences of the cholera toxin beta chain including the amino-acids that are thought to be involved in toxin-receptor binding have been synthesized using the solid phase method. They were then purified by gel permeation and ion exchange chromatography. Both these free peptides induced serum antibodies recognising the native toxin after oral or intraperitoneal administration. Only the antibodies raised against the 50-75 peptide, however, were able to neutralize toxin activity.

Dates et versions

hal-02146978 , version 1 (04-06-2019)

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Citer

A. Delmas, A Guyon-Gruaz, H Halimi, D Raulais, P Rivaille. Solid phase synthesis of two cholera toxin B subunit antigens.. International Journal of Peptide and Protein Research, 1985, 25 (4), pp.421-4. ⟨10.1111/j.1399-3011.1985.tb02195.x⟩. ⟨hal-02146978⟩
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